RT Book, Section
A1 Eckstein, Olive
A1 Allen, Carl
A1 McClain, Kenneth
A2 Kline, Mark W.
SR Print(0)
ID 1182911833
T1 Histiocytic Disorders
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182911833
RD 2024/04/19
AB Histiocytic  disorders  arise  from  abnormal  development  or  function  of  histiocytes,  which  literally  means  “tissue  cells.”  However,  we  remain  loyal  to  the  archaic  nomenclature  for  histiocytosis  that  is  meant  to  encompass  all  cells  of  the  mononuclear  phagocytic  system.  The  histiocytic  umbrella  therefore  covers  a  wide  range  of  disorders,  from  physiologic  reaction  to  inflammatory  stimuli  to  dysregulated  differentiation  and  proliferation.  This  chapter  will  focus  on  the  most  common  histiocytic  disorders  in  children,  including  Langerhans  cell  histiocytosis  (LCH),  juvenile  xanthogranuloma  (JXG),  Rosai-Dorfman  disease,  and  hemophagocytic  lymphohistiocytosis  (HLH).