RT Book, Section
A1 Ediger, Tracy R.
A1 Hill, Ivor D.
A2 Kline, Mark W.
SR Print(0)
ID 1182908310
T1 Disorders of Digestion and Absorption
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182908310
RD 2024/04/23
AB The  assimilation  of  ingested  nutrients  involves  a  complex  integrated  process  of  digestion  and  absorption  with  subsequent  transport  of  the  breakdown  products  across  the  intestinal  mucosa  into  the  systemic  circulation.  Normal  digestion  and  absorption  are  discussed  in  Chapter  376.  The  term  malabsorption  is  broadly  used  to  characterize  abnormalities  of  both  digestion  and  absorption.  The  schema  in  Table  403-1  lists  the  major  pathogenic  mechanisms  of  various  specific  malabsorptive  disorders  that  generally  are  due  to  disorders  in  luminal  digestion,  mucosal  function,  or  lymphatic  transport.  Malabsorption  may  involve  multiple  nutrients  (as  occurs  with  celiac  disease  or  pancreatic  insufficiency)  or  only  a  single  molecule  (as  found  in  isolated  glucose-galactose  malabsorption  or  vitamin  B12  malabsorption).  Defects  may  be  congenital,  with  onset  of  symptoms  shortly  after  birth,  or  acquired,  when  the  age  of  onset  of  symptoms  is  variable.