RT Book, Section
A1 Ng, Vicky Lee
A2 Kline, Mark W.
SR Print(0)
ID 1182909324
T1 End-Stage Liver Disease
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182909324
RD 2024/04/19
AB End-stage  liver  disease  in  infants  and  children  presents  a  number  of  medical  and  psychosocial  challenges  to  the  clinical  care  team.  While  many  of  these  complications  are  similar  to  those  in  adults  with  end-stage  liver  disease,  infants  and  children  with  end-stage  liver  disease  have  unique  characteristics  requiring  special  attention  by  healthcare  providers.  A  wide  variety  of  liver  diseases  may  progress  to  cirrhosis,  a  final  common  histologic  pathway  characterized  by  diffuse  fibrosis  and  conversion  of  the  normal  liver  architecture  into  structurally  abnormal  nodules  (Fig.  420-1).  However,  there  is  often  a  poor  correlation  between  histology  and  the  clinical  status  of  the  patient.  Some  patients  with  cirrhosis  are  essentially  asymptomatic  (compensated  cirrhosis),  whereas  others  have  all  of  the  sequelae  of  chronic  liver  disease  (decompensated  cirrhosis)  discussed  below.