RT Book, Section
A1 George, Alex
A2 Kline, Mark W.
SR Print(0)
ID 1182909969
T1 Hemoglobinopathies
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182909969
RD 2024/04/24
AB Normal  hemoglobin  (Hb)  structure  and  developmental  changes  in  production  are  detailed  in  Chapter  425.  Thousands  of  variants  in  the  α-,  β-,  minor,  and  fetal  globin  genes  have  been  described,  some  of  which  are  associated  with  tremendous  morbidity  or  mortality.  However,  most  hemoglobin  variants  have  no  clinically  significant  effect  on  hemoglobin  or  red  blood  cell  (RBC)  function.  A  continuously  updated  listing  of  Hb  variants,  many  of  which  are  named  after  the  town  or  geographic  regions  where  they  were  identified  (eg,  Hb  Köln),  is  provided  in  the  HbVar  database  at  http://globin.cse.psu.edu/hbvar/menu.html.