RT Book, Section A1 Paredes, Nethnapha A1 Berry, Leslie R. A1 Chan, Anthony K. C. A2 Kline, Mark W. SR Print(0) ID 1182910042 T1 Normal and Abnormal Hemostasis T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182910042 RD 2024/11/06 AB The hemostatic mechanism is a dynamic system that maintains the fluidity of blood while allowing for the formation of blood clots to prevent bleeding subsequent to blood vessel injury. These interrelated components consist of vessel walls (including endothelial cells), platelets, coagulation factors, inhibitors, and the fibrinolytic mechanism. Perturbation of any of these systems can lead to disease states that are thrombotic or hemorrhagic in nature. This chapter discusses the normal and abnormal hemostatic system in children, with emphasis on disorders involving the endothelium, platelets, and defects in coagulation and fibrinolysis.