RT Book, Section A1 O’Connor, Matthew J. A2 Kline, Mark W. SR Print(0) ID 1182914467 T1 Pericardial Disease T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182914467 RD 2024/04/23 AB The pericardium serves as the external protective layer of the heart, providing a barrier to trauma, malignancy, inflammation, and infection. In addition, a thin layer of fluid within the pericardial space lubricates the heart, thereby reducing the energy expenditure and shear stress encountered with cardiac motion. A basic understanding of the anatomy and physiology of the pericardium and pericardial space is necessary to recognize and properly diagnose disease processes affecting this important structure.