RT Book, Section A1 Rozenfeld, Ranna A. SR Print(0) ID 1152488158 T1 Heart Transplantation T2 The PICU Handbook YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259834370 LK accesspediatrics.mhmedical.com/content.aspx?aid=1152488158 RD 2023/06/06 AB Heart transplantation can be utilized in patients with end-stage heart failure that is refractory to medical and surgical management.Common indications for transplant:Cardiomyopathy requiring IV inotropes or mechanical respiratory or circulatory supportPalliated congenital heart disease with heart failure requiring IV inotropes or prostaglandin E (PGE) and/or mechanical supportPatients with heart failure due to cardiomyopathy or congenital heart disease that leads to severe limitation of exercise/activity or growthPatients with life-threatening arrhythmias untreatable with medications or an implantable defibrillatorRelative contraindications to transplant:Severe multiorgan system diseaseSevere pulmonary hypertension that is refractory to medical managementHistory of another medical condition that limits life expectancy in such a way that it would shorten graft survivalSevere psychosocial issues that may limit family's ability to care for the patient postoperatively