RT Book, Section A1 Rozenfeld, Ranna A. SR Print(0) ID 1152489063 T1 Acute Liver Failure T2 The PICU Handbook YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259834370 LK accesspediatrics.mhmedical.com/content.aspx?aid=1152489063 RD 2024/04/20 AB Symptoms may include nausea, vomiting, itching, fever.Signs may include encephalopathy, ascites, scleral icterus/jaundice.Though there are no strict diagnostic criteria, consider acute liver failure if all of these are present:Hepatic failure within 8 weeks of onset of hepatic diseaseElevated serum AST, ALT, and/or bilirubinCoagulopathy (PT >15, INR >1.5) does not correct with vitamin KNo prior history of chronic liver diseaseEncephalopathy (confirmatory, not required)