RT Book, Section
A1 Pelton, Stephen I.
A2 Kline, Mark W.
SR Print(0)
ID 1182934537
T1 Community-Acquired Pneumonia in Children
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182934537
RD 2024/04/20
AB Worldwide,  community-acquired  pneumonia  (CAP)  is  a  leading  cause  of  infectious  morbidity  and  mortality  in  children.  A  major  clinical  challenge  persists—determining  the  role  of  viral  and  bacterial  pathogens  in  pediatric  pneumonia.  Studies  that  employ  blood  and  respiratory  cultures,  serology,  and  molecular  detection  suggest  a  small  role  for  bacterial  pathogens,  while  those  that  rely  on  pneumococcal  conjugate  vaccines  (PCVs)  as  a  probe  to  determine  the  proportion  of  disease  due  to  Streptococcus  pneumoniae  suggest  that  pneumococcus  is  the  major  pathogen.  Evolving  insight  from  epidemiologic,  molecular  detection,  and  vaccine  probe  studies  suggests  that  viral-bacterial  interactions  have  a  substantial  role  in  the  pathogenesis  of  pediatric  pneumonia.  In  addition,  the  importance  of  comorbid  illness  as  a  risk  factor  for  both  increased  incidence  and  poorer  outcomes  of  pneumonia  has  emerged  from  recent  studies.