RT Book, Section
A1 Schleiss, Mark R.
A2 Kline, Mark W.
SR Print(0)
ID 1182935766
T1 Haemophilus influenzae
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182935766
RD 2024/04/19
AB The  types  of  infectious  diseases  caused  by  Haemophilus  influenzae  have  changed  considerably  in  recent  years  as  a  result  of  the  widespread  implementation  of  routine  childhood  immunization  against  type  b  organisms,  but  the  organism  remains  an  important  pathogen.  There  are  2  major  categories  of  disease  caused  by  H  influenzae:  infections  caused  by  unencapsulated  strains  (nontypeable  [NTHi])  and  disease  induced  by  encapsulated  strains  (typeable).  The  unencapsulated  strains  are  responsible  chiefly  for  infections  at  mucosal  surfaces,  including  conjunctivitis,  otitis  media,  sinusitis,  and  bronchitis.  In  contrast,  encapsulated  strains  are  associated  with  invasive  disease.  Of  the  6  encapsulated  strains,  type  b  in  particular  is  associated  with  septicemia,  meningitis,  cellulitis,  septic  arthritis,  epiglottitis,  and  pneumonia.  Prior  to  the  availability  of  an  effective  vaccine,  H  influenzae  type  b  (Hib)  was  the  most  common  cause  of  pediatric  bacterial  meningitis  in  the  United  States.