RT Book, Section
A1 Peters, Mark J.
A1 Brierley, Joe
A2 Kline, Mark W.
SR Print(0)
ID 1182925939
T1 Early Management of Sepsis and Septic Shock
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182925939
RD 2024/04/20
AB Sepsis  has  been  defined  in  adults  and  children  in  terms  of  changes  in  vital  signs  (heart  rate,  respiratory  rate,  temperature)  and  white  cell  count  in  the  context  of  infection  (Table  106-1).  The  systemic  inflammatory  response  syndrome  previously  described  the  same  response  in  the  absence  of  confirmed  infection  (eg,  after  trauma  or  major  surgery).  Over  the  past  decade,  the  Surviving  Sepsis  Campaign  has  made  important  efforts  to  develop  consensus  statements  defining  sepsis,  sepsis  syndrome,  septic  shock,  and  the  SIRS  in  adults.  The  first  set  of  guidelines  were  introduced  in  2008  and  were  updated  in  2012  and  again  in  2016  (Sepsis-3).  These  consensus  statements  included  updated  definitions  for  sepsis,  sepsis  syndrome,  septic  shock,  and  the  systemic  inflammatory  response  syndrome,  as  well  as  evidence-based  guidelines  and  algorithms  for  the  management  of  these  conditions  in  adults.  In  this  framework,  sepsis  is  described  as  “a  life-threatening  organ  dysfunction  caused  by  a  dysregulated  host  response  to  infection.”  Although  new  consensus  definitions  have  not  yet  been  developed  for  the  pediatric  population,  this  description  can  be  applied  to  patients  of  all  ages.