RT Book, Section
A1 Shenoi, Rohit P.
A1 Rubalcava, Daniel M.
A2 Kline, Mark W.
SR Print(0)
ID 1182927494
T1 Temperature Dysregulation
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182927494
RD 2023/04/02
AB Healthy  humans  are  able  to  self-regulate  their  body  temperature  within  a  narrow  range  (37±0.4°C  or  98.6±0.8°F),  despite  wide  variations  in  ambient  temperature.  Temperature  regulation  is  performed  by  the  thermoregulatory  center  in  the  preoptic  anterior  hypothalamus,  which  integrates  impulses  transmitted  by  the  peripheral  warm  and  cold  receptors  of  the  skin  and  the  central  thermoreceptors  located  in  the  hypothalamus,  spinal  cord,  viscera,  and  great  veins.  Normally,  the  body  maintains  a  balance  between  the  heat  generated  by  the  muscles  and  liver  and  the  heat  lost  through  the  skin  and  lungs.  During  exercise,  there  may  be  as  much  as  a  4-fold  increase  in  heat  production.  In  febrile  states,  homeostatic  mechanisms  such  as  vasoconstriction  and  shivering  raise  the  body  temperature  by  increasing  heat  production  and  decreasing  heat  dissipation  until  a  new  elevated  set  point  is  reached.  When  the  illness  abates,  the  set  point  returns  to  the  original  lower  level.  Lowering  of  the  body  temperature  is  heralded  by  the  onset  of  sweating.