RT Book, Section A1 Gozal, David A1 Kheirandish-Gozal, Leila A2 Kline, Mark W. SR Print(0) ID 1182915762 T1 Disorders of Respiratory Control and Sleep-Disordered Breathing T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182915762 RD 2024/03/28 AB The neuronal and musculoskeletal components of the respiratory system mature postnatally, whereas the systems governing respiratory control in general, and more specifically rhythmogenesis, must be mature and functional by birth to enable the successful transition from fetus to infant. In newborn infants, whose chest wall is highly compliant, rhythmical respiration must be coordinated with other behaviors including sucking, swallowing, crying, and other vocalizations. Premature infants display deficiencies of central respiratory rhythmogenesis or of activation of respiratory musculature. However, such problems are not restricted to this particular stage of life, and alterations in the control of breathing may play a role in many conditions that become apparent throughout childhood and adolescence, particularly during sleep. During sleep, the clinical manifestations of many diseases of respiratory control as well as other conditions affecting the respiratory system in general are more likely to emerge. Thus, understanding the pathogenesis of breathing problems is an important component of the clinical evaluation of any child with respiratory symptoms.