RT Book, Section
A1 Loomba-Albrecht, Lindsey
A1 Styne, Dennis M.
A2 Kline, Mark W.
SR Print(0)
ID 1182921010
T1 Abnormal Pubertal Development
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182921010
RD 2024/04/23
AB Early  pubertal  development  is  referred  to  as  sexual  precocity  or  precocious  puberty.  Central  precocious  puberty  is  a  term  reserved  for  children  with  gonadotropin-releasing  hormone  (GnRH)-dependent  early  puberty  that  follows  the  normal  pubertal  pattern  and  the  normal  control  mechanisms  through  GnRH.  Central  precocious  puberty  can  be  idiopathic  or  caused  by  organic  conditions  such  as  a  central  nervous  system  (CNS)  tumor.  GnRH-independent  isosexual  precocity  or  peripheral  precocious  puberty  is  caused  by  excessive  estrogen  secretion  in  girls  or  androgen  secretion  in  boys  from  sources  other  than  the  GnRH-gonadotropin  axis  (such  as  the  gonads  or  the  adrenal  glands)  or  by  ectopic  human  chorionic  gonadotropin  (hCG)  secretion.  Exogenous  sources  of  sex  steroids  will  also  cause  peripheral  precocious  puberty.  Pituitary  gonadotropins  are  suppressed  by  negative  feedback  in  all  forms  of  peripheral  precocious  puberty  because  sex  steroid  secretion  is  autonomous.  Contrasexual  (or  heterosexual)  precocity  refers  to  girls  who  virilize  and  boys  who  feminize.