RT Book, Section A1 Thompson, Trevonne M. A1 Erickson, Timothy B. A2 Tenenbein, Milton A2 Macias, Charles G. A2 Sharieff, Ghazala Q. A2 Yamamoto, Loren G. A2 Schafermeyer, Robert SR Print(0) ID 1155748647 T1 Opioids T2 Strange and Schafermeyer's Pediatric Emergency Medicine, 5e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259860751 LK accesspediatrics.mhmedical.com/content.aspx?aid=1155748647 RD 2024/10/04 AB Opioid toxicity is characterized by the classic triad of central nervous system depression, respiratory depression, and miosis.Some opioids, such as methadone, can have prolonged clinical effects.Some opioids—propoxyphene, meperidine, tramadol—can precipitate seizures.Supportive care and the use of naloxone are the mainstays of management.