RT Book, Section
A1 Lu, Jenny J.
A2 Tenenbein, Milton
A2 Macias, Charles G.
A2 Sharieff, Ghazala Q.
A2 Yamamoto, Loren G.
A2 Schafermeyer, Robert
SR Print(0)
ID 1155749051
T1 Isoniazid
T2 Strange and Schafermeyer's Pediatric Emergency Medicine, 5e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259860751
LK accesspediatrics.mhmedical.com/content.aspx?aid=1155749051
RD 2024/04/18
AB Isoniazid  (INH)  toxicity  should  be  considered  in  any  patient  with  metabolic  acidosis  and  seizures  refractory  to  conventional  therapy.Altered  sensorium,  slurred  speech,  ataxia,  coma,  and  seizures  can  occur  rapidly  after  an  INH  overdose.INH  toxicity  is  associated  with  profound  metabolic  acidosis  and  increased  serum  lactate.The  antidote  for  INH  poisoning  is  pyridoxine  (vitamin  B6).  Administer  an  amount  of  pyridoxine  equivalent  to  the  amount  of  INH  ingested  on  a  gram-for-gram  basis.  If  the  ingested  dose  is  unknown,  administer  70  mg/kg  (up  to  a  total  of  5.0g)  and  repeat  if  seizures  persist.