RT Book, Section
A1 Top, Karina A.
A1 Langley, Joanne M.
A2 Shah, Samir S.
A2 Kemper, Alex R.
A2 Ratner, Adam J.
SR Print(0)
ID 1157323708
T1 Infections in Asplenic Children
T2 Pediatric Infectious Diseases: Essentials for Practice, 2e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259861536
LK accesspediatrics.mhmedical.com/content.aspx?aid=1157323708
RD 2022/08/13
AB Once  regarded  as  an  unessential  organ  that  could  be  removed  without  adverse  effects,  the  spleen  and  its  significance  in  host  defense  against  infections  were  not  well  recognized  until  1952,  when  King  and  Shumacker  published  a  seminal  paper  describing  an  association  between  splenectomy  and  subsequent  susceptibility  to  overwhelming  infection.1  Since  then,  severe  infection  in  asplenic  individuals  has  become  a  well-known  entity,  termed  postsplenectomy  sepsis  or  overwhelming  postsplenectomy  infection.  This  chapter  provides  an  overview  of  the  basic  functions  of  the  spleen  and  the  infectious  complications  associated  with  asplenia  and  hyposplenia.