RT Book, Section A1 Leone, Tina A. A2 Siassi, Bijan A2 Noori, Shahab A2 Acherman, Ruben J. A2 Wong, Pierre C. SR Print(0) ID 1161424551 T1 Persistent Pulmonary Hypertension in Newborn Infants: Assessment of Pulmonary Artery Pressure* T2 Practical Neonatal Echocardiography YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781260123135 LK accesspediatrics.mhmedical.com/content.aspx?aid=1161424551 RD 2024/03/28 AB Pulmonary hypertension exists as a pathologic finding in newborn infants in several clinical settings. In the early newborn period, the syndrome of persistent pulmonary hypertension of the newborn (PPHN) can occur, consisting of failure of the fetal circulation to adapt to postnatal newborn physiology, mainly because of a persistent elevation in pulmonary vascular resistance. PPHN can occur as a primary pathology or secondary to pulmonary diseases such as meconium aspiration syndrome, pneumonia, pulmonary hypoplasia, or pulmonary/intrathoracic anomalies. Pulmonary hypertension can also occur after the early newborn period as a consequence of chronic pulmonary diseases such as bronchopulmonary dysplasia, or in association with congenital heart disease. At a physiologic level, pulmonary hypertension can be caused by increased pulmonary vascular resistance, by increased pulmonary blood flow, or by obstruction to pulmonary venous drainage. While the measurements of pulmonary artery pressure are similar no matter what the cause, some of the associated echocardiographic findings and the clinical scenarios will differ. The primary problem might not be easily discernible by echocardiography alone. However, assessment of the hemodynamics can often assist the clinician in choosing appropriate therapies.