RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164061747 T1 Aniridia T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accesspediatrics.mhmedical.com/content.aspx?aid=1164061747 RD 2024/10/07 AB It is estimated that approximately one-third of patients with sporadic aniridia will develop a Wilms tumor (nephroblastoma), while this risk increases to approximately one half of patients if aniridia, genitourinary anomalies (eg, hypospadias), and mental retardation are simultaneously present. The association with genitourinary anomalies and mental retardation is known as ☞WAGR Syndrome. Most patients have prominent lips and macrognathia. Other features may include congenital cataracts, nystagmus, ptosis, and blindness. The presence of ptosis and generalized hypotonia in a subgroup of patients reportedly suggests a susceptibility to malignant hyperthermia.