RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164067497 T1 Darier-White Disease T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accesspediatrics.mhmedical.com/content.aspx?aid=1164067497 RD 2024/10/07 AB A slowly progressive disorder involving the skin and causing severe keratinization. The lesions usually coalesce and result in crusted papillomatous lesions, sometimes accompanied with pus. The papules are also known as keratotic papules, keratosis follicularis, or dyskeratosis follicularis. Milder forms are more common and usually consist of skin rashes that flare up under certain conditions such as high humidity, stress or wearing tight-fitting clothes. The diagnostic is often established with the presence of poorly formed fingernails containing longitudinal white and red striations. This feature is pathognomonic. The onset may be as early as teenage years, but typically is observed during the third decade.