RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164072336 T1 Hemoglobin C Disease T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accesspediatrics.mhmedical.com/content.aspx?aid=1164072336 RD 2024/10/07 AB Genetically inherited hemolytic anemia, usually mild and often inapparent until adulthood. This disease is mainly encountered in populations of African descent, but also in populations of Sicilian and Hispanic descent. Hemoglobin C (Hb C) is one of the most common structural hemoglobin variants in the human population. Persons with hemoglobin C trait (Hb AC) are phenotypically normal, with no clinically evident limitations or symptoms, while those with Hemoglobin C Disease (Hb C) may have a mild degree of hemolytic anemia, splenomegaly, and borderline anemia.