RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164072450 T1 Hemophilia B T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accesspediatrics.mhmedical.com/content.aspx?aid=1164072450 RD 2024/10/07 AB Hereditary coagulation disorder caused by defective synthesis of plasma protein factor IX. It is the second-most common form of hemophilia, rarer than hemophilia A. The clinical hallmark of hemophilia B is articular hemorrhage. This bleeding is painful and leads to long-term inflammation and deterioration of the articulation. It is typically present in children and affects the ankles, whereas it more often involves the knees and elbows in adolescents and adults. These complications results in permanent articular deformities, misalignment, loss of mobility, and lead to extremities of unequal lengths.