RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164077765 T1 Marfan Syndrome T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accesspediatrics.mhmedical.com/content.aspx?aid=1164077765 RD 2024/03/29 AB It is a familial disorder characterized by generalized connective tissue abnormalities leading to abnormal tissue weakness with hyperextensible joints, eyes (dislocation of the lens), increased risk of acute aortic valve dissection, and spontaneous pneumothorax. The leading cause of mortality in the infancy period is the progression from mitral valve prolapse to acute regurgitation, often in conjunction with tricuspid regurgitation, leading to congestive heart failure and death.