RT Book, Section
A1 Bissonnette, Bruno
A1 Luginbuehl, Igor
A1 Engelhardt, Thomas
SR Print(0)
ID 1164078242
T1 MELAS Syndrome
T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259861789
LK accesspediatrics.mhmedical.com/content.aspx?aid=1164078242
RD 2024/04/16
AB MELAS  is  an  acronym  that  stands  for  Mitochondrial  myopathy,  Encephalopathy,  Lactic  Acidosis,  and  Stroke.  It  is  a  progressive  neurodegenerative  disorder  that  is  part  of  a  family  of  mitochondrial  cytopathies  that  includes  MERRF  and  Leber’s  Hereditary  Optic  Neuropathy  (see  Other  conditions  to  be  considered  below).  It  is  characterized  by  early  symptoms  of  generalized  seizures,  recurrent  headaches,  loss  of  appetite,  and  recurrent  vomiting.  Stroke-like  episodes  with  temporary  hemiparesis  muscle  weakness  may  also  occur,  affecting  consciousness,  vision,  hearing,  motor  skills,  and  intellectual  functions.  Other  clinical  features  include  diabetes  mellitus,  deafness,  episodic  vomiting,  seizures,  and  cortical  blindness.