RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164079869 T1 Myotonic Dystrophy T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accesspediatrics.mhmedical.com/content.aspx?aid=1164079869 RD 2024/03/28 AB It is a congenital anomaly of an ionic channel resulting in a multisystemic disease with anomalies of skeletal, smooth, and cardiac muscles. It may cause mental deficiency and alopecia. Clinically, the most obvious features are muscle rigidity and lack of muscle relaxation after contraction. The onset of the disease occurs during early adulthood. However, it may occur at any age and is extremely variable in degree of severity. Progression of the disease is slow, sometimes evolving over 50 to 60 years. There appear to be at least two forms.