RT Book, Section
A1 Bissonnette, Bruno
A1 Luginbuehl, Igor
A1 Engelhardt, Thomas
SR Print(0)
ID 1164088446
T1 Xeroderma Pigmentosum (XP)
T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259861789
LK accesspediatrics.mhmedical.com/content.aspx?aid=1164088446
RD 2024/10/08
AB A  syndrome  characterized  by  a  defect  in  ultraviolet  radiation-induced  deoxyribonucleic  acid  (DNA)  repair  mechanisms  and  by  a  severe  sensitivity  to  all  sources  of  ultraviolet  radiation  (especially  sunlight).  XP  is  categorized  into  seven  complementation  groups  according  to  the  capacity  of  the  body  to  repair  DNA  (XPA  to  XPG)  and  XPV  (variant,  second  decade  of  life).  The  DNA  damage  is  cumulative  and  irreversible.  Skin,  eyes,  and  nervous  system  affected  depending  on  group.  Major  risk  of  skin  cancers.