RT Book, Section A1 Gomella, Tricia Lacy A1 Eyal, Fabien G. A1 Bany-Mohammed, Fayez SR Print(0) ID 1168356988 T1 Pneumothorax T2 Gomella's Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 8e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781259644818 LK accesspediatrics.mhmedical.com/content.aspx?aid=1168356988 RD 2024/04/24 AB An infant with respiratory distress may have a pneumothorax. A pneumothorax is the abnormal accumulation of air in the pleural space, between the visceral and parietal pleura. It can develop spontaneously (idiopathic or from underlying lung disease) or be secondary to trauma. Pathophysiology involves an increased intra-alveolar pressure, which causes alveolar rupture and results in interstitial air; this air then dissects along the perivascular spaces and ruptures into the pleural space. A pneumothorax occurs more commonly in the neonatal period than any other time in life. Incidence is approximately 1% to 2% in term newborns and approximately 6% in premature infants. A pneumothorax is generally characterized as spontaneous, traumatic, tension, or persistent.