RT Book, Section A1 Gomella, Tricia Lacy A1 Eyal, Fabien G. A1 Bany-Mohammed, Fayez SR Print(0) ID 1168357171 T1 Acute Kidney Injury T2 Gomella's Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 8e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781259644818 LK accesspediatrics.mhmedical.com/content.aspx?aid=1168357171 RD 2024/03/28 AB There is no unified definition of acute kidney injury (AKI), previously termed acute renal failure, in neonates. Historically, neonatal AKI is defined as absolute serum creatinine ≥1.5 mg/dL, regardless of age or urine output, with normal maternal renal function. In 2013, a panel of experts at a National Institutes of Health-sponsored workshop proposed the adaptation of the categorical modified Kidney Disease: Improving Global Outcomes (KDIGO) definition to predict neonatal clinical outcomes (Table 86–1). According to neonatal KDIGO definition, AKI is defined as an absolute rise of ≥0.3 mg/dL or a ≥50% rise from lowest baseline serum creatinine. AKI can be anuric (absence of urinary output by 24–48 hours of age), oliguric (urine output of 1.0 mL/kg/h). AKI can present with normal urinary output (seen in asphyxiated neonates). Normal urine output is approximately 1 to 3 mL/kg/h with almost all infants voiding within 24 hours of birth. See Table 73–1.