RT Book, Section A1 Gomella, Tricia Lacy A1 Eyal, Fabien G. A1 Bany-Mohammed, Fayez SR Print(0) ID 1168358172 T1 Persistent Pulmonary Hypertension of the Newborn T2 Gomella's Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 8e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781259644818 LK accesspediatrics.mhmedical.com/content.aspx?aid=1168358172 RD 2024/03/28 AB Persistent pulmonary hypertension of the newborn (PPHN) is a condition characterized by marked pulmonary hypertension resulting from elevated pulmonary vascular resistance (PVR) and altered pulmonary vasoreactivity, leading to right-to-left extrapulmonary shunting of blood across the foramen ovale and the ductus arteriosus, if it is patent. It is associated with a wide array of cardiopulmonary disorders that may also cause intrapulmonary shunting. When this disorder is of unknown cause and is the primary cause of cardiopulmonary distress, it is often called idiopathic PPHN or persistent fetal circulation.