RT Book, Section A1 Gomella, Tricia Lacy A1 Eyal, Fabien G. A1 Bany-Mohammed, Fayez SR Print(0) ID 1168358311 T1 Spontaneous Intestinal Perforation T2 Gomella's Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 8e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781259644818 LK accesspediatrics.mhmedical.com/content.aspx?aid=1168358311 RD 2024/03/29 AB A spontaneous intestinal perforation (SIP) is a single intestinal perforation typically involving the antimesenteric border of distal ileum and usually occurs in extremely premature infants in the first 1 to 2 weeks of life. These infants, typically, have not been fed (or have received minimum feeds). If laparotomy is performed, a focal hemorrhagic necrosis with well-defined margins is observed, in contrast to ischemic and coagulative necrosis seen in necrotizing enterocolitis (NEC). The bowel proximal and distal to the perforation appears normal.