RT Book, Section A1 Capucilli, Peter A1 Brown-Whitehorn, Terri A2 Shah, Samir S. A2 Ronan, Jeanine C. A2 Catallozzi, Marina A2 Frank, Gary SR Print(0) ID 1185342329 T1 Allergy and Asthma T2 The Philadelphia Guide: Inpatient Pediatrics, 3e YR 2022 FD 2022 PB McGraw Hill PP New York, NY SN 9781260117882 LK accesspediatrics.mhmedical.com/content.aspx?aid=1185342329 RD 2024/04/24 AB Anaphylaxis is an acute, potentially life-threatening systemic allergic reaction. It is most commonly triggered by interaction of an allergen with specific IgE antibody bound to mast cells and basophils, leading to cell activation and mediator release. Non–IgE-mediated direct mast-cell degranulation can also result in mediator release.