RT Book, Section A1 Gozzo, Yeisid F. A1 Gallagher, Patrick G. A2 Shah, Samir S. SR Print(0) ID 6910462 T1 Chapter 50. Congenital TORCH Infections T2 Pediatric Practice: Infectious Disease YR 2009 FD 2009 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-148924-9 LK accesspediatrics.mhmedical.com/content.aspx?aid=6910462 RD 2024/03/29 AB Congenital TORCH infections comprise a group of diseases that affect the fetus and the newborn. Classically, the term TORCH represented Toxoplasmosis, other, traditionally referring to syphilis, rubella, cytomegalovirus (CMV), and herpes simplex virus (HSV). Recent additions to the acronym have expanded its repertoire to include infections such as human immunodeficiency virus (HIV), enterovirus, parvovirus, and varicella. These congenital infections share many clinical manifestations. Consequently, the differential diagnosis of one TORCH infection includes the remaining TORCH infections. The prevalence of the TORCH infections is variable. Infection due to rubella and toxoplasmosis is rarely seen in the United States, while CMV is common, representing a significant public health concern. Table 50–1 lists the classically defined TORCH infections and their common manifestations weighted according to their prevalence among infected neonates. The following chapter will discuss the epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, and management strategies for affected infants.