RT Book, Section
A1 Pine, Timothy R. La
A1 Hill, Harry R.
A2 Shah, Samir S.
SR Print(0)
ID 6912740
T1 Chapter 59. Evaluation of the Child with Suspected Immune Deficiency
T2 Pediatric Practice: Infectious Disease
YR 2009
FD 2009
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-148924-9
LK accesspediatrics.mhmedical.com/content.aspx?aid=6912740
RD 2024/04/20
AB Primary  immune  deficiencies  represent  a  class  of  disorders  in  which  there  is  an  intrinsic  defect  in  the  immune  system.  In  contrast,  acquired  or  secondary  immune  deficiency  states  occur  as  a  consequence  of  external  agents  such  as  infection  or  chemotherapy.  Over  150  distinct  primary  immune  deficiency  syndromes  have  been  recognized.  The  true  prevalence  of  primary  immune  deficiencies  is  not  known  as  routine  screening  for  these  defects  is  not  performed  at  birth  or  at  any  time  during  life.  One  well-conducted  telephone  survey  of  10,000  households  found  that  the  population  rate  for  the  diagnosis  of  primary  immune  deficiency  was  0.0863%,  which  translates  into  approximately  250,000  persons  (95%  confidence  interval:  151,769  to  361,408)  with  primary  immune  deficiency  in  the  United  States.46