RT Book, Section
A1 FontáN, Julio PéRez
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 6720244
T1 Chapter 102. Respiratory Distress and Failure
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=6720244
RD 2024/04/19
AB In  healthy  individuals,  respiratory  and  circulatory  functions  are  linked  to  tissue  metabolic  activity  by  a  responsive  regulatory  system  that  translates  biochemical  and  neural  signals  from  the  tissues  into  adjustments  in  cardiac  output,  vascular  tone,  and  minute  ventilation.  The  purpose  of  this  system  is  to  assure  that  all  the  cells  in  the  organism  receive  a  supply  of  O2  commensurate  with  their  metabolic  needs  without  accumulating  excessive  amounts  of  CO2.  The  system  relies  both  on  local  circulatory  reflexes,  which  alter  the  caliber  of  the  supplying  blood  vessels  in  accordance  with  tissue  metabolic  activity,  and  on  central  circulatory  and  respiratory  reflexes,  which  adjust  the  pumping  function  of  the  heart  and  the  intensity  of  the  respiratory  effort  in  response  to  changes  in  the  concentration  of  the  respiratory  gases  in  the  blood.1