RT Book, Section
A1 Tuchman, Mendel
A1 Lichter-Konecki, Uta
A1 Batshaw, Mark L.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 6725643
T1 Chapter 145. Urea Cycle and Related Disorders
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=6725643
RD 2024/04/25
AB Ammonia  is  a  degradation  product  of  nitrogen-containing  compounds  (mainly  proteins  and  amino  acids)  and  is  generated  by  the  metabolism  in  all  living  organisms.  Dietary  protein  contains  approximately  16%  nitrogen,  and  the  excess  nitrogen  from  the  amino  acids  that  are  not  incorporated  back  into  proteins  is  excreted  in  the  urine  as  urea.  Urea  is  produced  in  the  liver  by  an  enzymatic  process  that  is  dependent  on  an  intact  urea  cycle.  When  the  urea  cycle  malfunctions,  urea  is  produced  and  nitrogen  in  the  form  of  ammonia  accumulates  in  blood  and  tissues.