RT Book, Section A1 Clayton, Peter T. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 6727156 T1 Chapter 164. Disorders of Cholesterol Synthesis T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=6727156 RD 2024/10/10 AB The isoprenoid synthesis pathway (Fig. 164-1) leads to the synthesis of cholesterol (an important constituent of cell membranes and a precursor of steroid hormones and bile acids), haem A (a component of complex IV of the respiratory chain), ubiquinone (an electron carrier in the respiratory chain), dolichol (which is required for glycosylation of proteins), farnesyl-pyrophosphate, and geranylgeranyl-pyrophosphate (which are important for prenylation of proteins).1 Prenylation of proteins is important in many signaling cascades in the cell.