RT Book, Section
A1 Clayton, Peter T.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 6727156
T1 Chapter 164. Disorders of Cholesterol Synthesis
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=6727156
RD 2024/04/19
AB The  isoprenoid  synthesis  pathway  (Fig.  164-1)  leads  to  the  synthesis  of  cholesterol  (an  important  constituent  of  cell  membranes  and  a  precursor  of  steroid  hormones  and  bile  acids),  haem  A  (a  component  of  complex  IV  of  the  respiratory  chain),  ubiquinone  (an  electron  carrier  in  the  respiratory  chain),  dolichol  (which  is  required  for  glycosylation  of  proteins),  farnesyl-pyrophosphate,  and  geranylgeranyl-pyrophosphate  (which  are  important  for  prenylation  of  proteins).1  Prenylation  of  proteins  is  important  in  many  signaling  cascades  in  the  cell.