RT Book, Section A1 Jorde, Lynn B. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 6728549 T1 Chapter 171. Multifactorial Inheritance T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=6728549 RD 2024/03/29 AB Although the genetics of most single-gene disorders are now quite well understood, these disorders account for a relatively small proportion of the total disease burden in the pediatric population compared with diseases that are thought to arise from the interaction of multiple genetic and environmental factors. Examples of the latter include neural tube defects, congenital heart defects, isolated cleft lip/palate, and clubfoot. Many multifactorial disorders are present at birth and are thus considered to be congenital malformations, but others, such as infantile autism and type 1 diabetes, typically present later in childhood. This section will review basic concepts relating to the genetics of multifactorial disorders, with emphasis on diseases that occur in the pediatric population.