RT Book, Section A1 Carey, John C. A1 Bamshad, Michael J. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 6728787 T1 Chapter 175. Birth Defects, Malformations, and Syndromes T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=6728787 RD 2024/04/18 AB Birth defects are relatively common—about 2% of newborns will have a medically significant malformation recognized during the first day of life. However, approximately one half of all defects that are present at birth are not diagnosed until later in infancy. Defects that may not be apparent at birth include abnormalities of the central nervous system, cardiovascular system, and sensory systems (eg, hearing, vision) among others. Collectively, it appears that 4% of infants have a medically significant structural anomaly diagnosed by age 12 months.