RT Book, Section
A1 Garcia-Lloret, Maria
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7018540
T1 Chapter 191. Clinical Aspects of Allergic Diseases
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7018540
RD 2024/04/25
AB Allergic  rhinoconjunctivitis,  asthma,  and  food  allergy  are  some  of  the  prototypical  allergic  diseases.  While  allergies  may  develop  at  any  age,  allergic  sensitization  (ie,  development  of  IgE  responses)  occurs  predominantly  early  in  life.  Food-specific  IgE  antibodies  may  appear  in  the  very  young  to  herald  an  early  presentation  of  clinical  food  allergies.  Environmental  allergen-specific  IgE  antibodies  develop  mostly  after  the  age  of  2,  often  leading  to  allergic  rhinitis  and  or  allergic  asthma  in  preschool  or  school-aged  children.  Although  not  all  allergic  diseases  invariably  develop  in  the  same  patient,  in  a  sizeable  number  of  children  the  progressive  sensitization  to  multiple  antigens  will  result  in  sequential  and  often  cumulative  manifestations  of  atopy,  a  continuum  that  is  known  as  the  allergic  march  or  the  allergic  marathon.  It  follows  that  allergic  sensitization  in  childhood  can  have  long-lasting  effects  throughout  the  life  of  the  individual  and  implies  a  considerable  burden  to  society  as  a  whole.