RT Book, Section A1 Riedel, Marc A. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7018636 T1 Chapter 193. Anaphylaxis, Urticaria, and Angioedema T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7018636 RD 2023/03/22 AB Anaphylaxis, urticaria, and angioedema frequently share a common pathophysiology in that these conditions most commonly result from IgE-mediated mast cell activation resulting in the release of histamine, leukotrienes, and other mast cell mediators. Urticaria and angioedema are isolated to mucocutaneous symptoms whereas anaphylaxis is an acute systemic reaction that may rapidly lead to cardiopulmonary collapse.