RT Book, Section A1 Stovall, Stephanie H. A1 Jacobs, Richard F. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7021160 T1 Chapter 223. Bacteremia, Sepsis, and Septic Shock T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7021160 RD 2024/03/29 AB Children presenting with pathogenic bacteria in a blood culture (bacteremia) manifest a wide spectrum of clinical signs and symptoms. The continuum from bacteremia to sepsis, severe sepsis, and septic shock depends on a complex series of interrelated factors that include the specific etiology, the inoculum of organisms, strain variations or virulence factors, extracellular components or toxin production, the site of infection, the immunologic competence of the host, and the host response to the infection. Bacteremia may be occult, a transient phenomenon not associated with a specific focus of infection, or it may result from the extension of an invasive bacterial infection originating in the genitourinary, gastrointestinal, upper or lower respiratory tracts, or skin and soft tissues. Specific secondary infection (meningitis, osteomyelitis, pyelonephritis, peritonitis, intra-abdominal abscess, or facial cellulitis) may also occur and affect management. Recurrent or persistent bacteremia may result from established infectious foci (endocarditis, abscess, foreign-body infection).