RT Book, Section
A1 Steele, Russell W.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7021859
T1 Chapter 228. Fever of Unknown Origin
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7021859
RD 2024/04/24
AB The  definition  of  FUO  requires  an  immunologically  normal  host  with  oral  or  rectal  temperature  ⩾38.0°C  (100.4°F)  at  least  twice  a  week  for  more  than  3  weeks,  a  noncontributory  history  and  physical  examination,  and  1  week  of  outpatient  investigation.6-9  Early  diagnostic  studies  normally  include  a  complete  blood  cell  count;  lactate  dehydrogenase  (LDH);  uric  acid;  urinalysis  and  culture;  chest  roentgenogram;  tuberculin  skin  test;  erythrocyte  sedimentation  rate  (ESR)  or  C-reactive  protein  (CRP);  and,  in  the  older  child,  a  titer  of  antinuclear  antibodies.  Management  of  patients  with  comorbidity  factors  such  as  acquired  or  congenital  immunodeficiency,  neutropenia,  and  occurrence  of  fever  during  prolonged  hospital  stays  is  not  considered  in  the  following  discussion.