RT Book, Section
A1 Hong, David K.
A1 Prober, Charles G.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7024440
T1 Chapter 245. Antiviral Therapy
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7024440
RD 2024/10/11
AB Advances  in  molecular  virology,  with  the  identification  of  viral-specific  enzymes,  led  to  the  development  of  a  number  of  antiviral  agents.  Effective  antivirals  currently  are  available  for  the  management  of  infections  caused  by  herpes  simplex  virus  (HSV),  varicella-zoster  virus  (VZV),  cytomegalovirus  (CMV),  hepatitis  B  and  C  viruses,  influenza  A  and  B  viruses,  and  human  immunodeficiency  virus  (HIV).  To  maximize  therapeutic  efficacy,  treatment  should  be  initiated  as  early  in  the  course  of  infection  as  possible.  Under  some  circumstances  (eg,  recurrent  herpes  simplex  virus  infections  and  exposure  to  influenza  virus),  antivirals  may  be  effective  in  the  prevention  of  infection.  Development  of  resistance  to  antivirals  is  emerging  as  a  problem,  especially  in  the  immunocompromised  host  population  and  more  recently  with  influenza  viruses  circulating  in  the  general  population.