RT Book, Section
A1 Hong, David K.
A1 Prober, Charles G.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7024560
T1 Chapter 246. Antibacterial Therapy
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7024560
RD 2024/04/19
AB The  first  antibiotic  to  be  discovered  was  penicillin,  a  natural  product  of  Penicillium  mold.  Innumerable  microbial  products  have  been  investigated  since  then,  and  much  work  has  been  done  in  chemically  modifying  these  natural  products  in  an  attempt  to  enhance  the  benefits  while  minimizing  the  undesirable  effects.  These  modified  products,  termed  semisynthetic  antibiotics,  increased  stability  and  solubility,  improved  pharmacokinetics  (ie,  wider  distribution  and  longer  half-life),  and  increased  antimicrobial  activity.  Minimizing  the  undesirable  effects  creates  antibiotics  with  decreased  toxicity  and  increased  efficacy.