RT Book, Section A1 Flynn, Patricia M. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7024782 T1 Chapter 247. Antifungal Therapy T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7024782 RD 2024/04/23 AB Antifungal agents are available in systemic and topical formulations, and some are available in both forms. Topical antifungal agents, because they are poorly absorbed, are less likely to cause toxicity and should, as a rule, be the first choice for treating skin and mucous membrane infections. However, tinea capitis and onychomycosis (fungal infection of the nails) are best treated systemically (see Chapter 367). Infections that are severe, are disseminated, or involve the bloodstream should also be treated with systemic therapy. During the past 10 years, many potent new systemic agents have become available. Organism- and disease-specific antifungal therapies are summarized in Table 247-1.