RT Book, Section
A1 Schleiss, Mark R.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7029914
T1 Chapter 310. Cytomegalovirus
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7029914
RD 2024/04/19
AB Cytomegalovirus  (CMV)  is  one  of  the  family  of  eight  human  herpesviruses,  designated  as  human  herpesvirus  type  5  (HHV-5)  (Table  309-1).  Taxonomically,  it  is  referred  to  as  a  betaherpesvirus,  based  on  its  propensity  to  infect  mononuclear  cells  and  lymphocytes  and  on  its  molecular  phylogenetic  relationship  to  human  herpesvirus  type  6  (HHV-6)  and  human  herpesvirus  type  7  (HHV-7).  The  virus  consists  of  a  double-stranded  DNA  genome  of  >  240  kbp.  The  pathogenesis  of  CMV  infection  has  more  recently  been  the  subject  of  a  comprehensive  review.4  As  with  the  other  herpesviruses,  the  structure  of  the  viral  particle  is  that  of  an  icosahedral  DNA-contained  capsid,  surrounded  by  a  lipid  bilayer  outer  envelope  that  contains  the  virally  encoded  glycoproteins,  which  are  the  major  targets  of  host  neutralizing  antibody  responses.  The  proteinaceous  layer  between  the  envelope  and  the  inner  capsid,  the  viral  tegument,  contains  proteins  that  are  targets  of  host  cell-mediated  immune  responses.