RT Book, Section
A1 Hunt, Garrett
A1 Brady, Michael T.
A2 Rudolph, Colin D.
A2 Rudolph, Abraham M.
A2 Lister, George E.
A2 First, Lewis R.
A2 Gershon, Anne A.
SR Print(0)
ID 7029999
T1 Chapter 311. Epstein-Barr Virus Mononucleosis
T2 Rudolph's Pediatrics, 22e
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-149723-7
LK accesspediatrics.mhmedical.com/content.aspx?aid=7029999
RD 2024/04/16
AB The  Epstein-Barr  virus  (EBV)  is  recognized  as  the  major  cause  of  heterophil-positive  and  heterophil-negative  infectious  mononucleosis.  Manifestations  of  EBV  infection  are  varied  and  range  from  asymptomatic  infection  to  fulminant  lymphoproliferative  disease.  The  virus  is  associated  with  a  number  of  malignancies,  including  African  Burkitt  lymphoma,  nasopharyngeal  carcinoma,  Hodgkin  disease,  and  a  spectrum  of  posttransplant  lymphoproliferative  diseases.  The  specific  role  of  EBV  in  each  tumor  is  now  defined,  in  a  number  of  circumstances,  to  the  level  of  specific  cell  type  and  receptors,  intracellular  pathways,  gene  expression,  and  cytokine  production.