RT Book, Section A1 Dill, Sara W. A1 Cunningham, Bari B. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7033392 T1 Chapter 365. Acne and Other Disorders of the Pilosebaceous Unit T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7033392 RD 2024/03/29 AB Acne vulgaris is one of the most common cutaneous disorders and occurs in more than 85% of individuals between the ages of 12 to 24 years.1The degree of involvement is quite variable. Many individuals have mild to moderate disease of a transient nature; however, others develop severe disease that can lead to significant scarring and emotional distress. The onset of clinical disease usually occurs between the ages of 12 and 14 years, but mild disease may develop as early as 7 to 8 years of age and tends to occur somewhat earlier in girls than in boys. This prepubertal acne may be the first sign of pubertal maturation. Acne in this group is primarily comedonal and midfacial, favoring the forehead, nose, medial cheeks, and chin.2 Acne generally resolves in the late teens or early 20s, but persistence into the third decade or onset in middle age, particularly in women, is not unusual. Although most acne may be thought of as physiologic, disease with unusual features such as early onset or severe recalcitrance to therapy warrants evaluation for underlying abnormalities of the adrenal or ovarian systems.