RT Book, Section A1 Mayer, Alan N. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7035433 T1 Chapter 381. Normal Structure and Function of the Gastrointestinal Tract T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7035433 RD 2024/04/24 AB The gastrointestinal (GI) tract is a continuous tube beginning at the mouth and ending at the anus (Fig. 381-1). Its main function is to digest food and absorb nutrients and fluid. It is subdivided into 4 regions: (1) esophagus, (2) stomach, (3) small intestine, and (4) large intestine. The liver and pancreas directly communicate with the GI tract via ducts that join with the duodenum, the most anterior segment of small intestine. At the cellular level, the tissue architecture of the gut tube is similar throughout, consisting of 4 concentric layers.1 From inner to outer they are (1) mucosa, (2) submucosa, (3) muscularis propria (externa), and (4) adventitia or serosa. The mucosa is composed of epithelium, lamina propria, and muscularis mucosae (Fig. 381-2).