RT Book, Section A1 Noel, Richard J. A2 Rudolph, Colin D. A2 Rudolph, Abraham M. A2 Lister, George E. A2 First, Lewis R. A2 Gershon, Anne A. SR Print(0) ID 7036053 T1 Chapter 391. Gastrointestinal Disorders Associated with Immunodeficiency T2 Rudolph's Pediatrics, 22e YR 2011 FD 2011 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-149723-7 LK accesspediatrics.mhmedical.com/content.aspx?aid=7036053 RD 2024/03/29 AB Children with primary or acquired immunodeficiency are at increased risk for infectious and inflammatory gastrointestinal disorders.1 The risk and severity of infection depends on the type of immunodeficiency. Individuals with deficiencies of antibody response are predisposed to extracellular bacterial infections and intestinal pathogens. Patients with deficiencies of T cells are predisposed to both intracellular and extracellular infections. In addition, patients with primary immunodeficiencies are more prone to develop autoimmune disorders because of their decreased ability to distinguish self-organisms from foreign organisms. Autoimmune diseases and celiac disease are more common in the IgA-deficient patients.